Spurs made some interesting signings this summer with Matt Doherty and Pierre-Emile Hojbjerg joining, although they still remain without a real back-up for Harry Kane after loaning youngster Troy Parrott out to Millwall.
The Toffees also made some eye-catching moves in the transfer market, not least the high-profile capture of James Rodriguez from Real Madrid, and will be hoping to begin in positive fashion against a side they have not beaten since 2012.
Tottenham vs Everton Latest Odds
Tottenham vs Everton Team News
Giovani Lo Celso is the hosts' major absentee ahead of the season-opener, with the Argentina international having missed most of pre-season.
Everton have some holes in defence with Mason Holgate out, however Yerry Mina starts while James Rodriguez makes his Premier League debut.
Tottenham XI: Lloris, Doherty, Alderweireld, Dier, Davies, Hojbjerg, Winks, Dele, Lucas, Son, Kane
Everton XI: Pickford, Coleman, Mina, Keane, Digne, Allan, Gomes, Doucoure, James, Richarlison, Calvert-Lewin
Tottenham vs Everton Preview
Much of the attention on this game will surely be focused on James Rodriguez, with his signing certainly sending out a message that the Toffees are intent on seriously improving their 12th place finish from last term.
The Colombian should provide some world-class service into the box for Everton's forwards, something that was missing from Carlo Ancelotti's side last season.
Indeed, Everton's matches last season averaged 2.63 goals - one of the lowest totals in the division - with 20 of their games seeing less than three goals scored.
Spurs, though, conceded just 17 home goals last term, with only four teams shipping fewer, and the Tottenham Hotspur Stadium remains a tough place to visit.
Both games between these two sides in the previous campaigns were tight, low-scoring affairs and backing a similar clash on Sunday makes sense.
Tottenham vs Everton Tips And Predictions
Odds correct at the time of writing. Please gamble responsibly.