These two teams played out a 2-2 draw on Dutch soil last month to leave both clubs with just one point from their opening three group games and both teams know that failure to win this one will end their hopes of reaching the last 16.
Spurs are chalked up as 20/51 (1.39) favourites with SportPesa to keep their Champions League dream alive with victory against the Dutch league leaders.
Mark van Bommel's men have won each of their eleven league matches so far this season and, so, PSV will not be short of confidence ahead of Tuesday's tussle.
Dele Alli was not in Spurs' squad for the weekend win against Wolves, while Christian Eriksen came off the bench at Molineux but Pochettino will be hopeful that both men are fit to start this one.
Mousa Dembele limped off on Saturday and the Belgian midfielder looks likely to join Eric Dier, Danny Rose, Victor Wanyama and Jan Vertonghen on the sidelines for this clash. Hugo Lloris is banned after seeing red in the reverse fixture.
There have been at least three goals scored in seven of Spurs' eight Champions League clashes at Wembley and SportPesa go 20/43 (1.47) that there are more than two goals in this game.
The same firm go 6/5 (2.20) that Spurs score more than two goals - that play would have landed in both of Spurs' last two matches in all competitions.
Better value, though, could lie in backing at least four goals to be scored when these teams meet.
The 23/20 (2.15) selection would have landed in four of PSV's last five Champions League clashes on the road, as well as in four of Spurs' last six home ties in this competition.