Harry Kane broke the long-standing record for goals scored in a calendar year on Boxing Day as he netted a hat-trick in a thumping win, and Spurs have returned to that sort of form in the past two weeks.
Hugo Lloris is a doubt for the encounter due to illness, with Mauricio Pochettino unsure whether the France international will be fit to start in goal.
"I don't know [if Lloris will be fit]," Pochettino told reporters on Friday. "Difficult to say.
"We need to wait today and tomorrow and then assess him tomorrow and if he's available or not. I think it's a flu or a virus. It's between this."
Toby Alderweireld remains on the comeback trail but he is not yet fit to play and will miss the encounter this weekend.
Danny Rose is sidelined with a knee injury, while Harry Winks continues to struggle with a niggling ankle problem.
Spurs have no suspended players.
TOTTENHAM STARTING LINE-UP
Spurs were in fine fettle against Everton, turning on the style in the second half to blow away a woeful Toffees side, with Heung-Min Son in sparkling form on the left flank.
The South Korea international is likely to continue on the wing against Southampton, while Harry Kane will certainly lead the line.
If Hugo Lloris is unavailable then Michel Vorm is likely to deputise, though Paulo Gazzaniga kept a clean sheet on his debut in November.
Ben Davies is set to play at left-back, with Danny Rose still nursing an injury, while Mousa Dembele turned in an impressive midfield display against Everton and may partner Eric Dier.
SOUTHAMPTON TEAM NEWS
Southampton have few injury concerns, and are instead concerned about their form, having not won in the Premier League in almost two months.
Maya Yoshida faces a late fitness test after sustaining a hamstring injury, while striker Charlie Austin is expected to be out until February with a hamstring tear.
TV CHANNEL & KICK OFF TIME
The match takes place at 16:00 GMT (11:00 ET) on Sunday and will be shown live in the UK on Sky Sports Main Event and Premier League. Highlights can be caught on BBC's Match of the Day 2 at 22:30 GMT.
BEST OPTA MATCH FACTS
Southampton are winless in five home Premier League matches against Spurs since re-entering the top-flight in 2012 (D1 L4) - this after winning five in a row between 2000 and 2005.
Spurs have won their last three away Premier League games on a Sunday by an aggregate score of 13-2 - this is their first such match since their opening weekend win against Newcastle.
Mauricio Pochettino is yet to lose a Premier League game at St Mary's since he left Southampton at the end of the 2013-14 season, drawing one and winning two.
James Ward-Prowse has scored each of Southampton's last three goals in all competitions (one vs Fulham, two vs Watford) - he'd previously gone 25 games without a goal for them.