Spurs have stumbled in recent weeks, winning just one of their last five matches, but Mauricio Pochettino's team will hope to bounce back when they take on the Magpies.
Newcastle are targeting a top half finish but have been beaten in each of their last three Premier League matches, thus finding themselves in a five-way battle for 10th.
Rafael Benitez's side have won just one of their last eight matches on their travels and it is therefore no surprise that the Magpies are as big as 15/1 (16.0) with SportPesa to win this one.
Moussa Dembele and Harry Winks are again absentees for Spurs, whilst Newcastle will be without Christian Atsu, Jesus Gamez and the suspended Islam Slimani.
Seven of Spurs' last eight home victories has seen Pochettino's team chalk up a clean sheet and SportPesa go 4/5 (1.80) that the hosts keep Benitez's team at bay here.
The same firm go just 20/41 (1.49) that Tottenham (-1) come out on top in the handicap market - a selection that would have landed in all but one of Spurs' last 12 wins at Wembley.
Newcastle have kept just one clean sheet in their last 17 away matches and it could prove to be a long evening against a side desperate to claim victory and get within touching distance of a top four finish.
Tips and predictions
Spurs could claim a comfortable win here and SportPesa's 20/23 (1.87) quote for Pochettino's team to win to nil may represent good value for punters ahead of Wednesday's clash.