The Old Trafford outfit beat the north Londoners 1-0 earlier this season and there is every chance that Wednesday's game is another tight affair.
In the last six matches between these two sides, it has been the home team that has triumphed and Paddy Power offer Spurs at 5/4 (2.20) to pick up three points.
Spurs received a boost this week with Hugo Lloris, Toby Aldeweireld, Danny Rose, Erik Lamela and Christian Eriksen all returning to training.
However, Serge Aurier and Harry Winks look likely to remain unavailable for Wednesday's game.
Jose Mourinho has practically a fully fit squad to chose from, with Alexis Sanchez in line to make his Premier League debut for the Red Devils.
Solid defences to lead to few goals
For the last two seasons, Spurs have had the meanest defence in the Premier League but it is now United who have conceded the fewest goals in the top flight.
It is possible that Mourinho will prioritise avoiding defeat over claiming a win to keep the gap between the sides at a comfortable eight points.
Spurs have scored in their last 16 matches in all competitions, but we should not expect them to enjoy a free-scoring evening with the visitors likely to make things tough for them in the final third.
Tips and predictions
Opposing both teams to score has paid out in six of the last seven meetings between these sides and is offered at 11/10 (2.10). Under 2.5 goals has also proved profitable in four of the last seven games, and is priced at 5/6 (1.83).
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