Four point adrift of the champions after losing two consecutive matches in September, Spurs have won each of the subsequent four to close the gap to just two.
Having dropped just four points from the opening nine fixtures and boasting by far the best goal difference in the league, Pep Guardiola’s team are 3/4 (1.75) favourites to usurp leaders Liverpool with a victory here.
Just two of the last 28 meetings between this pair have resulted in draws, but you can get odds of 31/10 (4.10) on this one finishing up all square.
Dele Alli and Danny Rose could be in contention as they close in on a return to fitness, but Jan Vertonghen remains out until December with a hamstring issue.
Kevin De Bruyne is set to make his first league start of the season following his return from injury, although Eliaquim Mangala, Claudio Bravo, Ilkay Gundogan and Danilo are all sidelined.
Although they are just two points behind, Spurs’ general performances have been considerably less convincing than those of their guests in recent weeks.
Since their impressive 3-0 away victory over Manchester United in August, the Londoners have suffered four defeats in all competitions and recorded slender victories against relatively modest opposition in Brighton, Huddersfield, Cardiff and West Ham.
While this has allowed Tottenham to stay in touch with a Citizens team that has outscored them by 10 goals and conceded four fewer, it does not bode particularly well for a head-to-head encounter.
All in all, those 3/4 (1.75) odds actually look like good value on a City team that won both meetings between this pair by a 7-2 combined scoreline last season coming out on top once again.
Odds correct at the time of writing. Please gamble responsibly.