Mauricio Pochettino’s men went down 4-2 against the Spanish champions, bringing an end to their three-match unbeaten streak.
Nevertheless, they are 2/9 (1.29) favourites with bet365 to return to form by coming out on top against their newly-promoted visitors.
The Bluebirds are yet to record a victory in eight fixtures this season and arrive in the capital on the back of a five-game losing streak, but can be backed at 10/1 (11.00) to pull off a shock win here.
The hosts have gone 11 league matches without a draw, but there are odds of 11/2 (6.50) on this one finishing up all square.
Dele Alli, Christian Eriksen, Jan Vertonghen, Mousa Dembele and Serge Aurier are all ruled out through injury, although first choice goalkeeper Hugo Lloris returned to action against Barcelona.
Aron Gunnarsson, Lee Peltier and Nathaniel Mendez-Laing are long-term absentees for the guests, with Junior Hoilett set to return after missing last week's defeat to Burnley due to illness.
Despite the defeat against a Barcelona team inspired by the irrepressible Lionel Messi, Spurs should be in high spirits as they sit fourth in the table despite losing two of their seven opening league games.
Five wins from the other five league fixtures have ensured Pochettino’s team are still within touching distance of the early pace setters, and another three points look likely in this one.
Neil Warnock’s team have looked well out of their depth since returning to the top flight, with even their initial defensive solidity falling apart in recent weeks.
Considering the Welsh outfit have conceded 14 goals in their last four games, odds of 11/8 (2.38) are well worth backing on them suffering another heavy defeat as four goals or more are scored in Spurs’ third home league game in four.
Odds correct at the time of writing. Please gamble responsibly.