Spurs are legitimate title challengers this season, with Pochettino's side second and six points behind league leaders Liverpool after 19 rounds.
Tottenham – who did not sign any players before the transfer window shut in August – are the underdogs against Liverpool and City, drawing comparisons to Diego Simeone's Atletico.
"It's difficult to find another club doing the same or delivering the same work as us – the philosophy. Every single club is special and is different," said Pochettino, whose Tottenham are seeking their first league title since 1961.
"The investment from Atletico in players is bigger than ours. It is just below, but really close to, Real Madrid’s and Barcelona's budgets. They keep players like Antoine Griezmann and they signed Diego Costa.
"I think Atletico's budget is maybe bigger than any club in the Premier League. It is maybe five times bigger than the budget we have.
"It is more like Real or Barcelona. It is nothing like Tottenham. Do you think Atletico Madrid is comparable to Tottenham? Atletico Madrid are like City and Liverpool."