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Goal’s Jim Knight and Oliver Lines predictions for this week – aided by Opta Stats – can be found below.
West Bromwich Albion vs Southampton
With that in mind there could be plenty of squad rotation on show in the West Midlands and it's a tough game to call. The last three head-to-head meetings between these teams have gone to a replay so another draw could be a good option.
Prediction: West Brom 1-1 Southampton
Scorer: Sofiane Boufal
Oliver: Southampton won this exact fixture 3-2 just two weeks ago in the league, making it their third straight win over the Baggies.
Both sides have a more pressing issue on their minds in Premier League survival, so we could be in line for a dour affair between two rotated sides. However, Saints are unbeaten in four away from home and with six goals in those games, they should have enough to make it through.
James Ward-Prowse is responsible for four of those six, so he gets the nod to net the winner here.
Prediction: West Brom 0-1 Southampton
Scorer: James Ward-Prowse
Jim: Having already lost to Huddersfield once this season, Jose Mourinho will be acutely aware of the dangers of underestimating the Terriers. David Wagner's men will be flying high after their back-to-back 4-1 wins in the league but might come up short here.
The FA Cup now provides United with their only real chance of domestic silverware this term but they'll have one eye on their midweek trip to Sevilla. Nevertheless, Alexis Sanchez's record of eight goals in 15 FA Cup games makes him a solid play for Football 4Cast players.
Prediction: Huddersfield Town 1-2 Manchester United
Scorer: Alexis Sanchez
Oliver: Even with the magic of the FA Cup, it is very difficult to see the Terriers producing an upset here. Like every team in the bottom half of the Premier League, they are flirting dangerously with relegation and that will surely be David Wagner’s priority.
Man United thrive on these kind of games, and have not lost an away FA Cup game to a team outside the current ‘big six’ since 2002 when Middlesbrough ousted them 2-0.
Huddersfield will be sure to give them some trouble, but the class of the Red Devils should shine through by the end. Jesse Lingard loves the FA Cup and has a great opportunity to add to his two goals in the tournament this season.
Prediction: Huddersfield Town 0-2 Manchester United
Scorer: Jesse Lingard
Rochdale vs Tottenham Hotspur
Jim: Tottenham needed a replay to see off Newport County in the last round but they should be too good for Rochdale who have lost their last six FA Cup ties against top-flight opposition.
Heung-Min Son was a late substitute midweek so he could be a good option as a goalscorer play this weekend. The Korean has eight Premier League goals to his name this season and will be keen to try and secure more first team football after Erik Lamela's return from injury.
Prediction: Rochdale 0-2 Spurs
Scorer: Heung-Min Son
Oliver: Playing at Spotland is hardly likely to compare to Turin for Spurs, but similarly, there is hardly likely to be any complacency from them.
Mauricio Pochettino has played strong teams in each of the previous rounds and will likely follow suit here as they look to avoid adding a replay to a busy schedule.
Erik Lamela netted in the previous round against Newport County as he continues to recover from his hip injury, and will likely play in this one, so is good value to strike again here.
Prediction: Rochdale 0-3 Spurs
Scorer: Erik Lamela
Wigan Athletic vs Manchester City
Jim: Manchester City blasted their way past Basel and should send League One Wigan to a similar fate on Monday night. Pep Guardiola has so many attacking options to call upon that even a game sandwiched between a Champions League last 16 tie and a League Cup final is unlikely to prove too much of a headache.
Leroy Sane has recovered from his injury very quickly and made a cameo appearance on Tuesday night so he could be set for a start as he continues his comeback. The 22-year-old has four goals in five domestic cup starts this season.
Prediction: Wigan 1 Manchester City 3
Scorer: Leroy Sane
Oliver: Wigan have actually won the last two FA Cup matches between these sides, including their stunning 1-0 triumph in the 2013 final. That is not to suggest that they’ll make it three in a row here, but they shouldn’t be written off.
Man City are Man City and the story of their season does not need to be redocumented, even after their terrific win at Basel in midweek, but this game will be tougher than they maybe think.
A draw is certainly not beyond the realm of possibility, given that it will be a heavily rotated City team against a full-strength Athletic. Tournament top scorer Will Grigg is on fire this season, bagging six in six, and is a solid choice to net against the Citizens.
Prediction: Wigan 1-1 Manchester City
Scorer: Will Grigg