The Potters are currently three points adrift of safety with two games remaining, having played one match more than 17th-placed Swansea City.
Without a win in 12 fixtures, they are available at 6/4 (2.50) with bet365 to keep their hopes of escaping the drop alive with a timely victory here.
Looking far more comfortable as they sit six points clear of the drop, Roy Hodgson's men can be backed at 9/5 (2.80) to effectively consign their hosts to relegation by coming out on top.
The hosts have been held to a draw in each of their last three fixtures, and you can get odds of 9/4 (3.25) on them playing out another disappointing stalemate in this one.
Bruno Martins Indi and Konstantino Stafylidis have been ruled out through injury, while Glen Johnson and Eric Maxim Choupo-Moting both face late fitness tests.
Scott Dann, Jason Puncheon and Bakary Sako are missing for the Eagles, with Connor Wickham unlikely to feature due to a lack of match practice.
Having seen his side concede just 15 goals in the 13 matches since his appointment, Paul Lambert has certainly gone a long way to shoring up a defence that was the worst in the league when he arrived.
However, the former Wolves boss is still staring relegation in the face due to a lack of firepower, with the team having scored a measly nine times at the other end of the pitch.
While they may therefore back themselves to keep at bay a visiting attack that has scored only 14 goals in 18 away league matches this season, they should also struggle against a defence that has kept two consecutive clean sheets.
All in all, odds of 17/20 (1.85) offer strong value on under 2.5 goals being scored for Stoke's fourth game in a row, as well as a third in four on the road for Palace.