William Hill make the hosts 6/10 (1.60) favourites to make it a hat-trick of Group Four victories in Seville, having already beaten the Three Lions at Wembley.
Those who believe the underdogs can get their first Nations League victory can back England at 17/4 (5.25) with the same firm.
Bet £10 and get £10 on Spain v England
William Hill have a great offer on Spain v England and it's available to all eligible customers. Both new and existing players are included. T&Cs apply.
There's a link to the promotion page on the bookmakers' homepage. Press "Claim Here" then go to the match page.
Place £10 on any single or accumulator bet involving the match in question at odds of 1/5 (1.20) or better. Only your first wager on the match counts so be sure to place a minimum of £10 on it should you wish to claim the full amount.
Further bets can be placed on the game of course, but only your original selection will count for the purposes of this offer.
With hundreds of pre-match selections including #YourOdds which combine multiple elements from the same match into one bet, there's something for everyone at William Hill.
Prefer to wait until after the action has begun before picking your angle? In-Play selections will count for this offer as long as they meet the minimum stake and odds requirements.
Your account will automatically be credited with a free bet up the value of £10 (matching your original stake). These will be added to your account no later than 10am on Tuesday 16 October.
The free bet can be used on any market on any sport and doesn't expire for four days.
Monday's game will be of interest to plenty of punters and this offer makes placing a wager with William Hill even more attractive.