Jurgen Klopp's side slipped back down to fourth following Spurs' north London derby win over Arsenal on Saturday, but three points against the Saints will see the Reds reclaim the advantage in the intense race for a Champions League finish.
Just a single point separates the Merseyside outfit from Chelsea in fifth, so there is plenty at stake and they will be eager to avoid slipping up, particularly with a Champions League last-16 tie against Porto to come three days later.
Southampton, meanwhile, find themselves teetering perilously close to the relegation zone but, having ended an 11-game winless streak in the league last week, they will attempt to push further up the table with a home win.
|Game||Southampton vs Liverpool|
|Date||Sunday, 11 February|
|Time||16:30 GMT / 11:30 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Telemundo||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Premier League and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
Squads & Team News
|Goalkeepers||McCarthy, Taylor, Forster|
|Defenders||Cedric, Yoshida, Stephens, Hoedt, Bertrand, Gardos, Pied, Bednarek, McQueen|
|Midfielders||Davis, Tadic, Romeu, Ward-Prowse, Lemina, Boufal, Redmond, Hojbjerg, Sims, Hesketh|
|Forwards||Long, Obafemi, Austin, Carrillo, Gabbiadini|
Southampton have no suspensions to worry about and Pellegrino has plenty of options to choose from with most players fully fit.
Striker Charlie Austin is not one of those options though as he continues to recover from a torn hamstring.
Potential Southampton starting XI: McCarthy; Cedric, Bertrand, Stephens, Hoedt; Lemina, Romeu, Tadic, Ward-Prowse, Boufal; Long.
|Goalkeepers||Karius, Mignolet, Ward|
|Defenders||Clyne, Van Dijk, Lovren, Gomez, Klavan, Moreno, Robertson, Matip, Alexander-Arnold|
|Midfielders||Wijnaldum, Henderson, Milner, Lallana, Oxlade-Chamberlain, Can, Woodburn, Paulinho|
|Forwards||Firmino, Salah, Mane, Ings, Solanke, Brewster|
Joe Gomez will be unavailable due to a knee injury, but Nathaniel Clyne has resumed training and could find himself involved in the matchday squad.
Adam Lallana and Ragnar Klavan are both expected to be involved in some capacity after overcoming muscle injuries.
Potential Liverpool starting XI: Karius; Robertson, Matip, Van Dijk, Alexander-Arnold; Wijnaldum, Henderson, Oxlade-Chamberlain; Salah, Mane, Firmino.
Betting & Match Odds
Liverpool are favourites to win, with dabblebet offering odds of 4/5 on them. Southampton are priced at 7/2 and a draw is available at 11/4.
Liverpool missed an opportunity to further strengthen their top-four hopes last week when they were held to a 2-2 draw at home to rivals Tottenham and their frustrations were only exacerbated by a number of controversial refereeing decisions.
However, they will have to put that disappointment firmly behind them as they prepare to face a Southampton team that have been showing signs of gradual improvement in recent weeks.
There will be no shortage of gags in the build-up to the match with six former Southampton players returning to face their old club. Sadio Mane, Nathaniel Clyne, Adam Lallana and Dejan Lovren all arrived at Anfield from the Saints, while Alex Oxlade-Chamberlain began his career there.
The latest Reds raid on Southampton saw Virgil van Dijk make the trip north-west and, given the nature of his departure, the Netherlands international can expect a hostile reception on his return.
Of course, while Liverpool will be focused on the task at hand, they also have an away trip to Porto in the first leg of the Champions League last 16 to look forward to and Klopp will be keen for his players to come through the gauntlet unscathed.