Saints have secured just two wins from their last 15 Premier League matches on home soil and have collected just one point from two fixtures on their own patch this term.
The Seagulls have a wretched record on the road, though, with no win in 15 matches and failing to find the net in four of their last five league games away from the Amex Stadium.
It is no surprise, then, that the odds compilers offer 11/4 (3.75) that Hughton's men celebrate their first away win in the Premier League since November when they travel to Hampshire.
Southampton are a 21/20 (2.05) shot to secure victory, while William Hill's 11/5 (3.20) quote for the match to end in stalemate could prove popular, given that Saints have been inconsistent on home soil while Brighton have struggled on their travels in recent months.
Saints are sweating over the fitness of strike duo, Shane Long and Charlie Austin, although Danny Ings is available and is expected to lead the line for Hughes' hosts.
Jose Izquierdo and Florin Andone could be fit to feature for the first time this term for the Seagulls, who have no major injury concerns.
A low-scoring match?
Brighton have scored more than once in just one of their last 18 competitive matches away from home, while Saints have failed to net in four of their last seven Premier League matches at St Mary's.
Furthermore, there have been fewer than three goals scored in each of the last three renewals of this rivalry.
With neither side likely to be brimming with belief, Monday's meeting could take some time to get going and, so, real value could lie in backing the first 30 minutes of this clash to remain goalless at 21/20 (2.05) with William Hill.