The meeting is a repeat of last year's final which Barca won 5-0, while earlier this season Ernesto Valverde's side triumphed 4-2 against the Andalusians at Camp Nou in La Liga.
Sevilla have consistently made things tough for Barcelona at the Sanchez Pizjuan, drawing their last meeting there 2-2 in La Liga. Sevilla can be backed at 13/5 (3.60) to record a win while the Blaugrana are offered at 17/20 (1.85) and the draw at 3/1 (4.00).
Watch and bet live on Sevilla vs Barcelona
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Lionel Messi started Sunday's La Liga game against Leganes on the bench, but should come back into the starting eleven here. Ousmane Dembele is out, along with centre-back trio Jeison Murillo, Samuel Umtiti and Thomas Vermaelen all missing.
Sevilla have winger Nolito and midifelder Maxim Gonalons out injured.
This fixture tends to produce plenty of goals, although given this is a two-legged cup tie the approach may be a little different.
At home against the country's biggest sides, Sevilla tend to come flying out of the blocks roared on by their passionate home crowd only for their intensity to wilt in the second half.
This season however, the Andalusians have been generally much sharper in the second half of matches and in La Liga, 15 of their last 18 goals have come after the break.
Meanwhile four the last five league goals that Barcelona have conceded have come in the second half, so there should be some interest in investing in the hosts to find the back of the net after the break.
Tips and predictions
Sevilla to score in the second half is offered at 8/11 (1.72) and has paid out in seven of their last ten matches at home in all competitions. Both teams to score in the second half could also be a strong option and is priced at 6/4 (2.50).
Odds correct at the time of writing. Please gamble responsibly.