After making his debut for Nigeria a week ago, the youngster scored his second LaLiga - two weeks after opening his goal account in the Spanish top-flight - with his second-half effort at the Estadio de la Ceramica.
Santi Cazorla set the 19-year-old up for Villarreal's second goal two minutes after assisting Gerard Moreno for the opener in the 52nd minute.
#VillarrealRealBetis | 2-0 🚨 53' | GOOOOOOOOOOOOOOAAAAAAAAAAAAAAAALLLLLLLLLLLL by @chukwueze_8!!! @19SCazorla laid the ball back for the Nigerian youngster 🇳🇬 who made no mistake with a bullet of a strike into the far corner! 👌 pic.twitter.com/ZUCmQbrNdX — Villarreal CF English (@Eng_Villarreal) November 25, 2018
Chukwueze who was making his third LaLiga appearance fired in a left-footed shot past goalkeeper Pau Lopez to extend the team's dominance as Giovani Lo Celso's 90th-minute effort for Real Betis stood as a consolation.
The triumph ended Villarreal's seven-game winless run in the league and shot them out of the relegation zone to the 16th spot with 14 points from 13 matches.