Goals from Florian Thauvin and Clinton N'Jie saw Marco Rose's men go down 2-0 at the Stade Velodrome, leaving them up against it to make it through to the final.
However, having won seven and lost none of their last 10 European matches on home turf, they are available at 11/10 (2.10) with SportPesa to keep the tie alive with a victory here.
Die Roten Bullen have a fully fit squad to choose from, while their opponents could be without both Steve Mandanda and Hiroki Sakai.
Salzburg to strike back
Although clear underdogs to make it through to the final after the first-leg defeat, the home supporters will still believe that a comeback is possible given their team's form in this season's competition.
As well as going 10 games without defeat in their own back yard in Europe, the Austrian champions have already beaten Rudi Garcia's team 1-0 when the sides met here in September's group game.
What's more, they overcame a two-goal deficit to make it through the last round, losing 4-2 away to Lazio before running out impressive 4-1 winners in the return leg.
With Marseille having lost four of their last six Europa League away ties without scoring a goal, those 11/10 (2.10) odds look like solid value on a Salzburg outfit that has conceded just twice in eight matches in front of their own fans at least coming out on top here.