Juve also lost in the final to Barcelona in 2015 and are looking to bring an end to their 22-year stretch without a European crown this year.
"Ronaldo has something different, we are talking about a player who has won five Ballons d'Or," Matuidi said to Gazzetta dello Sport.
"We can say that he is the best in the world and we can only be happy to have him with us.
"For sure his experience is one of winning a lot, especially in the Champions League.
"It will help us in the crucial moments of the season. We will see it at work, this time on our side."
Ronaldo returns to Old Trafford on October 23 to face his former side, but he will have to share the spotlight with United midfielder Paul Pogba.
As reports continue to speculate about Pogba's relationship with Jose Mourinho, the World Cup winner has been linked with a return to Juventus, with Barcelona also said to be interested.
"We've been joking with Paul," Matuidi said of his France team-mate. "We’ve arranged to meet on the pitch in Manchester.
"Our group is hard, not just because of Manchester United, but also Valencia.
"They will be good matches though, we're prepared, we've been working hard in training to give it our all in the league and the Champions League.
“We have a very strong squad, with a lot of players who can express themselves over the season."