Santiago Solari's men have won just two of their last five matches in all competitions and their last home league match saw them suffer a 2-0 defeat against Real Sociedad.
Sevilla, meanwhile, have won just one of their last five competitive games, although they remain above Real Madrid in the table on goal difference.
The hosts are offered at 7/10 (1.70) with 888Sport to record their seventh home league win of the season. Sevilla have only won three matches on the road in the Primera Division this term and they are priced at 7/2 (4.50) with the draw on offer at 16/5 (4.20).
Real Madrid hope to welcome Karim Benzema back after the Frenchman dislocated a finger last weekend but the European champions will miss Gareth Bale, Marco Asensio, Toni Kroos and Thibaut Courtois.
Sevilla are without defensive midfielder Maxime Gonalons and winger Nolito.
Back in September, Sevilla recorded a fine 3-0 home win against Real Madrid and their record at the Estadio Sanchez Pizjuan against Los Blancos is excellent.
However, whilst the Andalusians have lost on each of their last 11 visits to the Bernabeu in all competitions, given Madrid's form and injury problems, Sevilla will feel this is a great chance to end that poor run.
The visitors can at least find the back of the net, having scored in seven of their ten away games this term, and in all seven of those matches they have netted in the second half.
Tips and predictions
Sevilla to score in the second half is offered at 89/100 (1.89) with Real Madrid conceding second half goals in three of their last five games at the Bernabeu.