Madrid have not lost a home match in the group stages for nine years and 888Sport price them at 1/12 (1.08) to record a win. The visitors meanwhile are offered at 29/1 (30.00) with the draw available at 12/1 (13.00).
Karim Benzema and Gareth Bale both started Saturday's game on the bench, but are likely to come back into the starting line-up on Tuesday.
Keylor Navas looks set to continue in goal in the Champions League ahead of Thibaut Courtois while Dani Carvajal remains unavailable at right-back. For the visitors, midfielder Jan Kopic is still out with a knee problem.
Real Madrid's problems have stemmed from a surprising inability to score, but surely they will end their barren run against Plzen.
The Czech champions were beaten 5-0 by Roma on matchday two, and their total of seven goals conceded in two matches gives them currently the worst defence in the competition.
With Madrid in need of a big performance on Tuesday, the Czech outfit might just be the perfect opponents for them to record the high-scoring win their fans have been waiting for.
Not only would such a result be a timely boost in this competition, but it would also be the ideal build up to the weekend Clasico meeting with Barcelona who will be without Lionel Messi.
Tips and predictions
The hosts are offered at 20/15 (2.33) to win with a -3 handicap and if Madrid rediscover their goalscoring touch they should be able to overcome Plzen with few problems. This bet requires Los Blancos to triumph by at least four goals.
Over the last four seasons Real Madrid have played 12 home games in the Champions League group stages and won five of those by a four goal margin.