With little but pride to play for in the league, Zidane should make plenty of changes against the side that was responsible for Los Blancos' shock exit from the Copa del Rey in January.
Leganes recorded a famous 2-1 at the Bernabeu three months ago and dabblebet price them at 9/1 (10.00) to triumph again.
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Given the upcoming Champions League showdown against Bayern Munich, Zidane is likely to rest many of the players he expects to start on Tuesday night.
Isco picked up a knock at the Allianz Arena, although he would have been unlikely to feature anyway, whilst the likes of Cristiano Ronaldo and Sergio Ramos will probably miss out.
Leganes are likely to be without talismanic centre-back Martin Mantovani.
Low-key affair at the Bernabeu
There is little riding on this game for either side, with Europe the number one priority for Madrid and safety having already been achieved by Leganes.
As such, there is every chance that the game will lack intensity and so opposing a high scoring encounter makes sense.
Lega's games have averaged the second fewest number of goals in La Liga this season, while Real Madrid will surely be saving their exertions for Tuesday night.
Tips and predictions
Under 2.5 goals is priced at a healthy looking 7/5 (2.40), with this bet paying out in both of Real Madrid's last two home league games.