Despite falling out of the Champions League at the group stages, Ralph Hasenhuttl's side recorded impressive victories over Napoli and Zenit St. Petersburg to progress to the last eight of this competition.
Leipzig are chalked up as SportPesa's 20/27 (1.74) favourites to take the initiative in the tie by claiming a home win here.
Marseille have won just one of their last eight away matches in this competition but that came in the previous round against Athletic Bilbao and will surely give Rudi Garcia's side confidence.
SportPesa go 15/4 (4.75) that the Ligue 1 side come out on top on German soil, while the same firm offer 11/4 (3.75) that the tie remains all square ahead of next week's return leg at Stade Velodrome.
Stefan Ilsanker is a major doubt for the hosts, while Marcel Halstenberg will not play again this season. Captain Willi Orban is suspended.
Marseille will be without top scorer Florian Thauvin due to a thigh complaint, whilst Steve Mandanda and Adil Rami will miss out after picking up injuries on the weekend.
Goals at both ends?
There have been goals at both ends in each of Marseille's last six matches in all competitions, while Leipzig have both scored and conceded in eight of their 10 European games this term.
It is therefore no surprise that SportPesa go 10/13 (1.77) that both teams are on target.
Tips and predictions
As such, there is plenty of potential for the goals to flow when these teams meet.
SportPesa's 10/13 (1.77) quote for more than two goals to be scored could represent good value for punters ahead of Thursday's Europa League first leg fixture in Leipzig.