Unai Emery's men should arrive at the Tofiq Bahramov Republican Stadium in high spirits, having won each of their last seven consecutive matches.
Despite failing to win either of their last two away matches in this competition, they are 4/9 (1.44) favourites with William Hill to maintain their fine form by coming out on top in Azerbaijan.
The Horsemen were defeated 2-0 by Sporting CP in their opening Europa League tie, but are available at 6/1 (7.00) to bounce back with a famous win in front of their own fans, or 17/5 (4.40) to claim a creditable point.
Henrikh Mkhitaryan has not travelled due to political tensions between Azerbaijan and his native Armenia, while Konstantinos Mavropanos, Carl Jenkinson, Ainsley Maitland-Niles, Laurent Koscielny and Petr Cech are all ruled out through injury.
Long-term absentee Dani Quintana is the only reported injury problem for the hosts, as he continues his recovery from ligament damage.
Having made history as the first Azerbaijani team to reach the Champions League group stages last season, Gurban Gurbanov's team endured a rather forgettable campaign that saw them score just twice in six matches.
Their European campaign has started in similarly low-scoring fashion this time out, failing to find the net in five of their nine fixtures so far.
With two consecutive clean sheets under their belt, the Gunners should feel confident of replicating the recent European guests Olimpija and BATE and keeping the hosts at bay once again.
All in all, odds of 5/4 (2.25) look like strong value on Arsenal winning to nil against a goal-shy Qarabag.