Willian gave Chelsea a first half lead against Manchester United at Old Trafford but goals from Romelu Lukaku and Jesse Lingard made it three defeats in four Premier League games for Chelsea.
The Blues are now 5/4 (2.25) to finish in the Champions League qualification spots, quite a fall from grace for the side who ended last season top of the pile and it could be another summer of uncertainty at Stamford Bridge.
Harry Kane's last gasp winner for Tottenham against Crystal Palace saw them leapfrog their London rivals into fourth spot and Mauricio Pochettino's men now have a two-point gap over the reigning champions.
They are now 2/7 (1.29) for a top four place together with Manchester United and Liverpool, who are both just 1/12 (1.08) to do likewise. Arsenal are huge outsiders at 20/1 (21.0) and understandably so given their poor form.
The Spurs advantage could widen after this weekend too, with Chelsea visiting runaway leaders Manchester City while Huddersfield Town travel to Wembley, where the hosts have won six of their previous seven Premier League games.
With City boasting a 13-point lead and another game in hand against Arsenal to come, one of the few competitive betting heats involving the elite clubs could be who will take second place.
Jose Mourinho is 6/5 (2.20) to ensure his side make it a one-two for the Manchester sides but Liverpool at 11/8 (2.38) could be an interesting bet, given the 10 games both sides have left to play this season.
The two rivals square off on 10 March but there's also a Manchester derby to come on 7 April.
Both teams involved at the Etihad might have one eye on the Champions League – the quarter finals land either side of this blockbuster clash - while Jurgen Klopp’s men head to Everton on the same weekend.
Liverpool travel to Chelsea in early May but other than that, every team they play between now and the end of the season is currently ninth or lower in the table.
United on the other hand, also have a tricky looking tie with Arsenal to contend with and the Reds certainly inspire more confidence based on their recent performances.
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