Goals from Paul Pogba and Marcus Rashford set up a 2-1 win over Brighton, moving them to within three points of fourth-place Chelsea and maintaining a 100 per cent record since Jose Mourinho departed.
The Red Devils were 14/1 (15.0) on December 21 to finish in a Champions League spot but maximum points since then, combined with the results of other top four rivals, has seen their odds cut each week.
On the reverse side, bet365 also offer 8/15 (1.53) that United fail to make the top four for the fourth time in the six seasons since Sir Alex Ferguson retired in 2013.
On top of Harry Kane being injured until at least March and Son Heung-min away at the Asian Cup, things got even worse in their 2-1 win over Fulham as Dele Alli limped off with a hamstring injury.
A tricky Carabao Cup second leg at Chelsea on Thursday is followed by an FA Cup visit to Crystal Palace on Sunday, who have taken five points from their eight matches against the ‘Big Six’ this season. Both look tricky encounters given the absentees Pochettino has to contend with.
Spurs' next three league games all come at home as the north London club host Watford, Newcastle and Leicester.
The Gunners can be backed at 7/2 (4.50) despite that much-needed victory – just their third win in their last seven league games – with the online bookmaker making it 1/5 (1.20) that they miss out on the Champions League again.