Two of the Dragoes’ three group stage victories were recorded in front of their own fans, while they have come out on top just three times in their last 12 away matches in this competition.
Eager to give themselves a lead to defend for the trip to Anfield, they are priced at 21/10 (3.10) to secure an important first-leg advantage by coming out top here.
The previous two encounters between these sides at this ground have both resulted in draws, and you can get odds of 13/5 (3.60) on them cancelling each other out once again in this one.
Sergio Conceicao is without the suspended Felipe, while Ivan Marcano, Vincent Aboubakar, Danilo Pereira and Andre Andre all face late fitness tests.
Jordan Henderson should come in for the suspended Emre Can in the visiting midfield, otherwise Klopp will likely pick the same team that saw off Southampton at the weekend.
Having scored more times than anyone but Paris Saint-Germain in the first round, the Reds will certainly back themselves to secure a priceless away goal against a defence that conceded six in their three home group games.
However, results such as the 2-2 and 3-3 draws against Sevilla in the previous round make it hard to anticipate a Liverpool clean sheet, particularly given Porto are averaging three goals per game at home.
All in all, odds of 20/21 (1.95) seem generous on both teams getting on the scoresheet in an entertaining clash that produces over 2.5 goals.
Odds correct at the time of writing. Please gamble responsibly.