United welcome rivals Liverpool to Old Trafford with both teams in fine form in the Premier League, particularly Pogba and Co.
A resurgence under manager Jose Mourinho has seen United go 15 matches unbeaten in all competitions and 11 in the Premier League to sit sixth in the standings and five points adrift of second-placed Liverpool.
And world-record signing Pogba is aware of the significance of the clash, putting it ahead of the Manchester City fixture.
"The history of fixture is well known. It is a big derby, more so than Manchester City," Pogba told BBC's The Premier League Show.
"The atmosphere is always very special.
"You want three points against any team, but it is more special when it comes against Liverpool."