Maurizio Sarri has made a sensational start to life in the Stamford Bridge dugout, leading his new team to top of the Premier League with five wins from five.
Razvan Lucescu's men knocked Spartak Moscow and Basel out of the Champions League qualifiers before being eliminated by Benfica, and are available at 3/1 (4.00) to pull off another impressive victory in this one.
Mateo Kovacic and Emerson have not travelled along with Eden Hazard and David Luiz, whilst Cesc Fabregas and Ruben Loftus-Cheek are both doubtful but have made the trip to Greece.
Leo Matos will miss this clash due to suspension, having picked up a red card against Benfica in the Champions League qualifiers.
As well as delivering instant results, Sarri has already treated the fans to far more entertaining football than that of predecessor Antonio Conte.
Leading the Premier League on goal difference after scoring 14 goals in five matches, the Blues should prove far too hot to handle for a home side that has conceded seven times in three European home games so far this season.
Nevertheless, having also scored six goals themselves in those three fixtures, PAOK will also fancy their own chances of hitting the net against a visiting team expected to rest some key players.
All in all, odds of 17/20 (1.85) look very appealing on over 2.5 goals being scored for Chelsea's fifth game in six this season, and a fourth consecutive European home game for their opponents.