The hosts look settled in mid-table but will be keen to defeat their rivals, who are hoping to protect their position in the top six.
Gary Rowett's men are 4/9 (1.44) with bet365 to finish in the play-offs, and retaining the Brian Clough Trophy here would only help their cause.
Derby are still looking for that elusive third win of 2018 to get their promotion challenge back on track.
They are 29/20 (2.45) to record a first victory at the City Ground since September 2012, making three points even more important for the Rams.
Lee Tomlin was ruled out of Tuesday’s 0-0 draw at Norwich and Forest will hope their mercurial maestro is fully fit here, but Karanka could name an elsewhere unchanged eleven.
Chris Cohen, Jack Hobbs and David Vaughan remain long-term absentees.
Chris Baird’s suspension means Andre Wisdom should start at right-back for Derby, while Jamie Hanson and Sam Winnall are still sidelined.
Value with Forest
The best value here can be found by siding with in-form Forest, who are 5/1 (6.0) to win with both teams scoring - a bet that would have come off in two of their last three games.
Although 10 places separate the sides in the Championship table, Derby have gone six matches without victory whilst Karanka's men are unbeaten in five.
Matty Cash has improved hugely since the change of manager and has netted two goals in his last three games, with the 20-year-old scoring first in a home win at 20/1 (21.0) potentially appealing to the more audacious punter.
Preview and predictions
For our best bet though, the Evens (2.0) price on Forest - Draw No Bet is too good to miss. That selection will land should the Tricky Trees take three points but the stake will be returned if the game ends all square.
Odds correct at the time of writing. Please gamble responsibly.