Newcastle won three successive Premier League matches last month and SportPesa go 19/10 (2.90) that Benitez's men find a return to winning ways this weekend.
Matt Ritchie is back for the Magpies after serving a one-match ban but Paul Dummett is doubtful, while Florian Lejeune is out.
Jonny Otto remains sidelined for Wolves, who could welcome back Ruben Neves after the Portuguese midfielder missed Wednesday's match against Chelsea through suspension.
Goals at a premium?
Wolves' 2-1 defeat at Cardiff last weekend was the first match that Santo's side have contested on their travels this season that has featured more than two goals.
Each of Wolves' previous seven away matches had seen fewer than three goals and SportPesa offer 10/17 (1.59) that there are no more than two goals on Tyneside.
The same firm offer 20/27 (1.74) that either side fails to find the net - that play would have landed in five of Wolves' eight matches away from home this season, as well as in four of Newcastle's last five fixtures at St James' Park.
However, both sides will be in buoyant mood after encouraging results and performances in midweek.
Indeed, the hosts have now lost just one of their last six games, while Wolves have found the net in four of their last five fixtures.
This tie, then, could be more entertaining than many observers are anticipating and the even money (2.0) quote for both teams to score could provide punters with a path to profit on Sunday afternoon.