The 25-year-old limped off the field in the closing minutes against Tottenham, leaving Newcastle down to 10 men, and he had to be helped up the stairs to the dressing room.
Newcastle went on to lose 2-1, and there were fears the right-back could be out an extended period.
Those fears have been calmed by Newcastle however, who announced in a statement: "The club can confirm that the knee injury sustained by DeAndre Yedlin on Saturday was not serious.
"He has been assessed and undergone treatment this week and is likely to resume training with his team-mates shortly."
It is not yet known if Yedlin will be ready for Newcastle's next match, a Premier League encounter at Cardiff on Saturday.