Sunday's 0-0 draw at Milan saw the Partenopei fall six points adrift of leaders Juventus, who they will face in a potential Scudetto decider this weekend.
Having come out on top in six of the last seven encounters between these teams, they are available at 2/11 (1.18) with bet365 to remain within touching distance of the top with a win here.
Massimo Oddo's future is hanging by a thread after seeing his side lose nine consecutive league fixtures, but he can be backed at 16/1 (17.00) to give his job security a major boost by overseeing a shock win in this one.
Three of the hosts' last five matches have resulted in draws, and there are odds of 6/1 (7.00) on offer on them being held to yet another stalemate on this occasion.
Kalidou Koulibaly is suspended after picking up a fifth yellow card of the season at the San Siro, while Faouzi Ghoulam remains a long-term injury absentee.
Valon Behrami, Kevin Lasagna and Gabriele Angella are all out injured, with Emil Hallfredsson also out through suspension.
Responsible for both his side's last two goals and one of only two players to find the net at all in the previous 10 fixtures, Lasagna's absence will come as a major blow for the Zebrette.
Without their top scorer, it is hard to see a visiting team that has scored just three times in seven away matches having much joy against a defence that has kept six clean sheets in nine games.
Instead, odds of 8/11 (1.73) are not to be missed on a strong Napoli side winning to nil for the fourth match in a row against struggling Udinese.