The fixture sees Massimiliano Allegri, who has masterminded a sensational start to the season, pit his wits against an under-pressure Jose Mourinho.
Juventus currently sit top of the Serie A table, having won a whopping 25 points from just nine games so far with eight wins and a draw. Mourinho's United, on the other hand, are languishing in the 10th spot with just 14 points from nine games.
But Allegri insists Manchester United will be a very difficult side to beat on Tuesday.
Interestingly, Cristiano Ronaldo is back at his old stomping ground while Man United ace Paul Pogba will be lining up against his former team for the first time.