Under-fire after negative comments made in the summer and following the Red Devils shock 3-2 loss to Brighton in their second game, Mourinho felt the pressure to deliver a big result at home against top-four rivals Tottenham.
A solid first half for the Red Devils, however, did not break the deadlock, and after the break Spurs dominated, scoring three goals through Harry Kane and a Lucas Moura double.
The result secured United's worst league start in 26 years , and down to 13th in the table, with the pressure only growing on Mourinho, who suffered his worst home defeat in his career in the process .
However, the manager struck a defiant tone following the loss, denying his team was not outmanaged despite the heavy beating.
"We worked all week and from the strategic point of view we didn't lose,” Mourinho told Sky Sports . “From the tactical point of view, we didn’t lose. But we lost the game.”
Mourinho then turned his attention to the United fans, who he was seen applauding right after the full-time whistle.
The manager continued that praise on the club’s faithful, saying they responded despite the ugly looking scoreline.
“But all our fans don't read papers. All of our fans don’t watch television. All our fans are more intelligent than that. They answered in absolutely amazing ways.
“I don't think it's normal for a team to lose at home and the supporters react the way they did.”
It was a similar tone Mourinho took in the pre-game lead up to the Monday night match, praising the fans while also refusing to offer the same support to his squad .
Manchester United are next in action August 29 at Turf Moor against Burnley.