Having kicked off the season with a 2-1 victory over Leicester City, Jose Mourinho's men suffered a shock 3-2 loss against a Seagulls side who are expected to be fighting against relegation once more this season.
A triumph for Mauricio Pochettino's side would see them keep up with early pace-setters Liverpool and it would heap further pressure on Mourinho, who desperately needs to put points on the board.
|Game||Manchester United vs Tottenham|
|Date||Monday, August 27|
|Time||8pm BST / 3pm ET|
TV Channel, Live Stream & How To Watch
In the United States (US) the game will be shown live on television on NBCSN, UNIVERSO and Telemundo Deportes. It can also be streamed live on the NBC Sports app.
|US TV channel||Online stream|
|NBCSN / UNIVERSO / Telemundo Deportes||NBC Sports app|
In the UK the game will be available to watch live on television on Sky Sports Premier League and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Premier League||Sky Go|
Squads & Team News
|Position||Manchester United squad|
|Goalkeepers||De Gea, Grant, Kovar, Romero|
|Defenders||Lindelof, Bailly, Jones, Smalling, Rojo, Young, Dalot, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, Andreas, Fred, Herrera, Fellaini, Matic, McTominay, Gomes, Hamilton|
|Forwards||Lukaku, Rashford, Martial, Sanchez, Chong, Bohui|
Mourinho has shuffled his deck following defeat at Brighton, with no less than six changes from that last Premier League outing.
Antonio Valencia, Nemanja Matic, Jesse Lingard, Phil Jones, Luke Shaw and Ander Herrera all start on Monday.
Man Utd XI: De Gea; Valencia, Smalling, Matic, Jones, Shaw; Pogba, Fred, Herrera; Lingard, Lukaku.
|Goalkeepers||Lloris, Vorm, Gazzaniga|
|Defenders||Vertonghen, Alderweireld, Sanchez, Trippier, Rose, Walker-Peters, Aurier, Foyth, Davies|
|Midfielders||Winks, Lamela, Wanyama, N'Koudou, Dier, Sissoko, Alli, Eriksen, Dembele, Onomah, Lucas, Amos|
|Forwards||Son, Kane, Llorente, Janssen|
Spurs will be without Heung-min Son, who is representing South Korea at the Asian Games, while Vincent Janssen is out of contention with an injury. Victor Wanyama, meanwhile, remains sidelined with a knee problem.
Spurs XI: Lloris, Trippier, Alderweireld, Vertonghen, Rose, Dier, Dembele, Eriksen, Lucas, Dele, Kane..
Betting & Match Odds
Manchester United are marginal favourites to win, with bet365 offering odds of 31/20 on a Red Devils victory at Old Trafford. Spurs are priced at 2/1 to win, while a draw is available at 23/10.
It has been a painfully long week for Manchester United and Mourinho following their surprise loss to Brighton last Sunday, but they will be able to set the record straight by responding appropriately against Spurs.
In the immediate aftermath of the 3-2 defeat against Chris Hughton's side, stand-in captain Paul Pogba was forthright in his criticism of the team, suggesting that their attitude was not good enough and that they did not prepare well enough for the challenge, while Mourinho complained about his players making too many mistakes.
The Red Devils boss was particularly morose about the entire affair, chiding a reporter for pondering whether or not his team lacked "chemistry" against the Seagulls and his pre-match press conference was a continuation of that theme as he showed up half an hour early, before leaving after just four minutes.
A sour atmosphere is gripping the club currently and it could well deteriorate further should they fail to pick up a win against Tottenham at Old Trafford on Monday.
Spurs will be eager to exploit the apparent disharmony that is afflicting United and, despite not adding any new faces to their squad during the transfer window, Pochettino's team are more than capable of upsetting their hosts.