Second-place United come into the tie having come from behind at Crystal Palace to win 3-2 and currently sit two points above Jurgen Klopp's side.
This will be the 170th meeting in league competition between the two sides, but who will come out on top in this one?
|Game||Man Utd vs Liverpool|
|Date||Saturday March 10|
|Time||12:30 GMT / 07:30 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|NBC Sports Live||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on Sky Sports Main Event and it can be streamed live online using Sky Go.
|UK TV channel||Online stream|
|Sky Sports Main Event||Sky Go|
Squads & Team News
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Lindelof, Bailly, Jones, Smalling, Rojo, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, Carrick, Young, Matic, McTominay, Gomes|
|Forwards||Martial, Rashford, Lukaku, Ibrahimovic, Sanchez|
Mourinho is tasked with finding a formula for his array of attacking outlets and could initially shape up with a midfield diamond, as he did against Chelsea, though he is likely to opt for a 4-3-3 formation.
United will be without Ander Herrera, Marouane Fellaini and Daley Blind for the game, while Anthony Martial missed Monday's win at Palace and is unlikely to return to the starting XI this time round.
Potential Man Utd XI: De Gea; Valencia, Bailly, Smalling, Young; McTominay, Matic, Pogba; Lingard, Lukaku, Alexis
|Goalkeepers||Karius, Mignolet, Ward|
|Defenders||Clyne, Van Dijk, Lovren, Gomez, Klavan, Moreno, Robertson, Matip, Alexander-Arnold|
|Midfielders||Wijnaldum, Henderson, Milner, Lallana, Oxlade-Chamberlain, Can, Woodburn, Paulinho|
|Forwards||Firmino, Salah, Mane, Ings, Solanke, Brewster|
Liverpool will line up with the the front trio which has served them so well this season; Mohamed Salah and Sadio Mane will play either side of Roberto Firmino.
The game will come too soon for Georginio Wijnaldum, but Alex Oxlade-Chamberlain will return to the starting XI after being rested against Porto in the week.
Potential Liverpool XI: Karius; Alexander-Arnold, Matip, Van Dijk, Robertson; Oxlade-Chamberlain, Henderson, Can; Salah, Firmino, Mane
Betting & Match Odds
United are slight favourites to win the game, with dabblebet pricing them at 13/8.
Liverpool are 7/4 to win the game and a draw is 23/10.
Saturday's game could hardly mean more for both sides.
The rivalry between the two clubs is a bitter one, and this time round the meeting could determine which of the two clubs finishes above the other come the end of the season.
Manchester City are runaway leaders this term with United and Liverpool directly below them in the Premier League table.
United have won 10 of their last 13 Premier League home games against the Reds, losing in 2008-09 and 2013-14, and drawing last season.
And while few teams go to Old Trafford and win, the Anfield outfit will be confident in picking up a result, such is their strength in front of goal.
Only City have scored more goals than Klopp's side, though the Reds have scored more times on the road than any other side in the English top tier.
Liverpool have also already booked their place in the Champions League quarter-finals, too, while United play their second leg against Sevilla just three days after they host their Merseyside opponents.
The fixture promises to kick the weekend's Premier League fixtures off with a bang on Saturday afternoon as the rivalry between the two sides continues.