Jose Mourinho's side were dumped out of Europe's premier club competition by Sevilla on Tuesday and the FA Cup is now their only realistic chance of winning silverware this season.
Indeed, the Red Devils stuttered to a narrow 1-0 win over Brighton when the sides met at the same venue back in November, so they know how difficult it can be to break the Seagulls down.
|Game||Manchester United vs Brighton|
|Date||Saturday March 17|
|Time||19:45 GMT / 15:45 ET|
|Stream (US only)||fubo TV (7-day free trial)|
TV Channel & Live Stream
In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial).
New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser.
|US TV channel||Online stream|
|Fox Sports 2 / Fox Sports Deportes||fubo TV (7-day free trial)|
In the United Kingdom (UK), the game can be watched live on TV on BT Sport 1 and it can be streamed live online using the BT Sport app.
|UK TV channel||Online stream|
|BT Sport 1||BT Sport app|
Squads & Team News
|Position||Man Utd players|
|Goalkeepers||De Gea, Romero, Pereira|
|Defenders||Lindelof, Bailly, Jones, Smalling, Rojo, Shaw, Valencia, Darmian|
|Midfielders||Pogba, Mata, Lingard, Carrick, Young, Matic, McTominay, Gomes|
|Forwards||Martial, Rashford, Lukaku, Ibrahimovic, Sanchez|
Manchester United will be without the services of Daley Blind and Ander Herrera, who are working their way back from ankle and thigh injuries respectively, while Zlatan Ibrahimovic is also working to regain match fitness. Phil Jones and Marcos Rojo will also miss out.
Potential Man Utd XI: De Gea; Valencia, Bailly, Smalling, Young; McTominay, Matic, Pogba, Mata; Sanchez, Lukaku.
|Goalkeepers||Ryan, Maenpaa, Krul|
|Defenders||Bruno, Bong, Hunemeier, Dunk, Duffy, Goldson, Schelotto, Rosenior, Suttner, Mateju|
|Midfielders||Stephens, Kayal, Skalak, Knockaert, Gross, Sidwell, March, Propper, Hutchinson, Molumby|
|Forwards||Baldock, Hemed, Ulloa, Murray, Izquierdo, Locadia, Connolly, Tilley|
Brighton will be without Steve Sidwell, who continues to work his way back from a back injury, while Jiri Skalak is unavailable. Chris Hughton has mixed things up in previous rounds, rotating his squad, but he is likely to deploy his first-choice against United.
Potential Brighton XI: Ryan; Schelotto, Dunk, Duffy, Bong; Propper, Stephens, Gross, Izquierdo, Kayal; Murray.
Betting & Match Odds
Manchester United are favourites according to dabblebet, who rate the Red Devils at 3/10 to win the match. Brighton are priced at 10/1 and a draw is available at 17/4.
Manchester United's season took a major blow during the week as they lost at home to see their Champions League hopes go up in smoke and Mourinho will be determined to bounce back from that disappointment by making an example of Brighton and progressing to the semi-finals of the FA Cup.
With cross-town rivals Manchester City set to wrap up the Premier League title in a matter of games, England's most presitigious trophy offers the Red Devils their only realistic shot at winning silverware this season, but they face a tricky opponent in the form of Hughton's Seagulls.
Brighton have been performing above expectations in the league since their promotion from the Championship, finding themselves in 11th place in the table, and in a demonstration of their capability for an upset they recently recorded a convincing victory over Arsenal.
A Lewis Dunk own-goal was all that separated the sides when they met in a closely fought encounter at Old Trafford last November but, having already suffered the ignominy of elimination from the Carabao Cup and the Champions League, United will be keen not to let the game come down to such fine margins on Saturday.
With the international break also looming on the horizon, the importance of the game has taken on a greater significance for Mourinho in particular, who will be desperate to avoid having to stew on a series of body blows to his side's campaign.