Unai Emery's men have lost eight and won none of their last 11 league visits to this ground, but come into this clash on the back of a 19-game unbeaten streak.
The Red Devils are eight points adrift of their opponents with just one win in four league matches, but can be backed at 7/5 (2.40) to bounce back by coming out on top.
Eric Bailly, Chris Smalling, Antonio Valencia, Matteo Darmian and Marcus Rashford will all face late fitness tests after missing the Saints game with minor injuries. Victor Lindelof and Alexis Sanchez are definitely ruled out through injury and Ashley Young suspended.
Granit Xhaka is suspended after picking up his fifth yellow card of the season on Sunday, while Mesut Ozil is still a doubt due to the back strain that has kept him out of the last two matches.
Despite their terrible record at this ground over the last decade or so, this match will hold little fear for the Gunners on current form.
Although usually adept at drawing competitive big-match performances out of players via resilient defensive tactics, it is hard to see even that working given the injury list and the fact his team has kept just two clean sheets in 14 league games.
Boasting the league's best goal-scoring record on the road this season, Arsenal actually look strong value at 2/1 (3.00) to compound United's misery by overpowering them in a memorable victory.