Having restricted Liverpool, Chelsea, Tottenham and Arsenal to just two goals between them this season, Manchester United face the biggest test to their defence so far when Manchester City visit Old Trafford on Sunday.
No team has scored more away goals at this ground than Pep Guardiola's men, who are averaging over three a game in this season's Premier League.
With eight strikes to his name in 11 previous appearances against the Red Devils, Sergio Aguero is dabblebet's 7/2 (4.50) favourite to open the scoring in this one, or even odds (2.00) to strike anytime for the 13th time in all competitions this campaign.
Meanwhile, Gabriel Jesus' impressive record reads 15 goals in 18 league starts since arriving from Palmeiras, and he is also priced at evens (2.00) to add to that in high-profile fashion in the derby.
Currently enjoying his most prolific season ever with 13 strikes from 15 starts, Raheem Sterling could offer excellent value at 2/1 (3.00) to hit the net in this one, while Leroy Sane is available at 15/8 (2.88) to add to his current total of eight.
At the other end of the pitch, Romelu Lukaku will be desperate to dispel doubts over his effectiveness in big games by coming to the fore in his first ever Manchester derby.
Undoubtedly the man for the big occasion, Zlatan Ibrahimovic is on offer at 6/4 (2.50) to complete his comeback from injury with a dramatic goal against the local rivals and add to his strike in last season's corresponding fixture.
Responsible for six goals in just seven league starts this season, Anthony Martial can be backed at 11/5 (3.20) to get on the scoresheet once again, while youngest ever Manchester derby goalscorer Marcus Rashford is available at 2/1 (3.00) to grab more headlines here.