However, Chris Hughton's men are currently enjoying a five-match unbeaten streak, and can be backed at 14/1 (15.00) to keep that going with a shock victory here.
The last league encounter between these sides finished in a 1-1 draw way back in 1983, and there are odds of 6/1 (7.00) available on them cancelling each other out once again a third of a century later.
Although the result does not change much in terms of their qualification chances, defeat in Basel was a third in four away matches for Jose Mourinho's team.
In contrast, they have shown no such vulnerability in front of their own fans, having now gone 38 fixtures without losing at Old Trafford in all competitions.
Despite their recent resurgence, it is hard to see the Seagulls posing any genuine threat to that record on Saturday.
All five of the opponents Brighton have faced during their five-game unbeaten run currently reside in the bottom seven, meaning it would take a major step up to leave this ground with anything to show for their efforts.
Averaging over three goals per game in their own back yard this campaign, odds of 8/11 (1.73) actually seem generous on United coming out on top in a match that features over 2.5 goals for their fifth time in seven at home.