Pep Guardiola's side are expected to sweep aside the struggling visitors, who have garnered just a single point from their opening three top flight matches.
As a result, punters will likely have to get creative in search of a big price at the Etihad Stadium on Saturday night, but SportPesa have a big new customer offer which could fit the bill.
Anyone opening a new online account can get a huge quote of 50/1 (51.0) on either Sergio Aguero or Gabriel Jesus scoring the first goal. £1 max bet. Winnings paid in bonuses. Terms and conditions apply.
Guardiola has favoured Aguero in the early part of the season and the Argentina international has already hit the net three times, all of which came against Huddersfield Town and included breaking the deadlock in that game.
He is certainly the main attraction of this enhanced price. The 30-year-old not only has a wealth of top-flight experience, but he has a fantastic record against this particular opposition too.
According to Opta data, Aguero has 14 goals in just 11 appearances against Newcastle. What's more, eight of those have come in his last two meetings with them at the Etihad Stadium.
Finally, those 14 strikes against the Magpies for Manchester City is a record for goals scored against an opponent for a single club.
Given those statistics plus the added bonus of getting Jesus thrown into the bargain at a huge enhanced price of 50/1 (51.0), this offer is expected to prove extremely popular in the run up to kick-off.
Benitez will likely set his team up in the same defensive formation that he deployed against Chelsea last time out so having a big price about two of the leading first goalscorer contenders from the home team makes a lot of sense.