The Citizens have lost two and drawn one of their previous three matches at the Etihad Stadium against their local rivals, surrendering a 2-0 half-time lead to go down 3-2 last campaign.
Having won eight and lost none of their nine home matches since that defeat, they are 2/5 (1.40) favourites with bet365 to exact revenge by coming out on top in this one.
Just two of the last 19 encounters between this pair have resulted in draws, but you can get odds of 4/1 (5.00) on this one finishing up all square.
Kevin De Bruyne is a long-term absentee for the hosts, with Claudio Bravo and Eliaquim Mangala also sidelined.
Romelu Lukaku remains a doubt after missing the last two matches due to a knee issue, while Alexis Sanchez also faces a late fitness after coming off injured in Turin.
City too strong
Although last season’s comeback win was a major shock considering City’s rampant form, the Red Devils will not be too disheartened if they fall behind once again on Sunday.
While they have conceded first in six of their last eight fixtures, Mourinho’s men have shown impressive resilience to only lose two of those games.
However, they may be pushing their luck to expect a similar recovery against Pep Guardiola’s team, who have conceded just twice in the previous 11 fixtures - winning 10 and losing none.
In fact, even odds (2.00) seem like solid value on the home side coming out on top after leading at halftime for their seventh game in a row, particularly given United’s habit of starting slowly.
Odds correct at the time of writing. Please gamble responsibly.