The Seagulls moved seven points clear of the drop with two games left to play thanks to a 1-0 victory over United on Friday, ending a run of seven fixtures without a win.
Having taken just four points from the last available 33 on the road, they are 26/1 (27.00) outsiders with bet365 to upset more Manchester opposition at the Etihad Stadium.
Meanwhile, Pep Guardiola’s men were held to a shock 0-0 draw by Huddersfield in their last clash, but are clear 1/8 (0.13) to favourites to cap a triumphant season by coming out on top in their final game on home turf.
Three of the guests’ last five away matches have resulted in draws, and you can get odds of 9/1 (10.00) on them claiming a point in this one.
Sergio Aguero is ruled out through injury, while David Silva is unavailable after returning to Spain due to personal reasons.
Aside from long-term injury absentee Steve Sidwell, Chris Hughton has the luxury of a fully fit squad to choose from.
After failing to score in a home league game for just the third time in 37 matches under Guardiola, the hosts will be keen to bounce straight back as they look to break Chelsea’s record of 103 goals in a Premier League season.
However, they will have to work hard to increase their current 102-goal haul when they take on Hughton’s side, which has conceded fewer goals on the road than all but the current top four teams.
Having frustrated United just days ago, odds of 5/6 (1.83) offer solid value on Brighton ensuring under 3.5 goals for their 17th away league game in 18, as well as their second game of the season versus City.
Odds correct at the time of writing. Please gamble responsibly.