The Red Devils currently languish in seventh place as they look to bounce back from a 2-2 draw at Southampton, while Arsenal will head into the fixture with added momentum after defeating north London rivals Tottenham 4-2 on Sunday.
Man Utd Injuries
United manager Jose Mourinho has a defensive crisis to deal with as he prepares for the meeting at Old Trafford, and will potentially have to name a makeshift back four for Wednesday.
Antonio Valencia, Chris Smalling and Eric Bailly are all injury doubts after missing the trip to Southampton, while Victor Lindelof has been ruled out of the upcoming clash with a groin problem.
The Man United boss may have to look to Diogo Dalot to fill in for Young at right-back as the England international is suspended for the tie in Manchester, with Nemanja Matic, Marcos Rojo and Matteo Darmian also defensive options.
Chile international Alexis Sanchez is not expected to make an appearance until after the new year with a torn hamstring, while Romelu Lukaku remains a slight doubt following his early substitution against Southampton on Saturday.
Man Utd Suspensions
Ashley Young is suspended for the clash after receiving his fifth yellow card of the season in Saturday's 2-2 draw at Southampton.
Man Utd Starting Line-Up
A much-changed defensive lineup is expected of the Red Devils as Mourinho deals with an onslaught of injuries, with the manager telling reporters: "We are going to be in difficulties again to build the team. We are again going to have to make adaptations and compensations to try to give some balance to the team."
Jesse Lingard, Juan Mata and Anthony Martial are all in contention for a starting role should Lukaku be deemed unfit for the clash at Old Trafford, while Mourinho could also be tempted to rest Rashford – despite the England international registering two assists against Southampton at the weekend.
Arsenal Team News
Mesut Ozil is a doubt for the clash and will be re-assessed ahead of Wednesday after missing out on the north London derby entirely due to a back issue.
Danny Welbeck has been ruled out for the foreseeable future following a broken ankle against Sporting CP, and Nacho Monreal is unavailable having picked up a hamstring problem.
Laurent Koscielny has returned to the squad following a long-term recovery from his Achilles issue, while Granit Xhaka is suspended for the match after collecting five yellow cards already this season.
TV Channel & Kick-off time
The match at Old Trafford kicks off at 8pm GMT and 3pm ET on Wednesday, with live coverage available on BT Sport 1 in the UK. In the US the game will be shown on NBCSN.
Best Opta Match facts
- Manchester United are unbeaten in their last 11 home Premier League games against Arsenal (W8 D3), since a 0-1 loss in September 2006.
- Arsenal lost both Premier League meetings with Manchester United last season – they last lost three in a row against them in November 2012.
- Arsenal have only scored more than once in three of their last 39 away league games against Man Utd – and they’ve lost all three of those games (2-4 in November 1984, 2-8 in August 2011 and 2-3 in February 2016).
- This is the first time Man Utd have hosted Arsenal in a midweek Premier League match since May 8th 2002, when Arsenal won 1-0 to clinch the title thanks to a Sylvain Wiltord strike.
- Manchester United have conceded 23 goals in their 14 league games this season; it wasn’t until their 30th Premier League game of 2017-18 that they conceded their 23rd goal last season.
- Man Utd boss Jose Mourinho has never previously lost in five meetings with Arsenal manager Unai Emery (W4 D1, all in La Liga), with this their first meeting since October 2013 (Mourinho’s Real Madrid beating Emery’s Sevilla 4-1).