Having lost two of their opening three games for the first time in 26 years, it is imperative that United get back on track with a win ahead of the first international break of the season, otherwise the next two weeks are going to be full of speculation relating to potential changes at the club.
Man Utd Injuries
Nemanja Matic and Antonio Valencia both returned against Spurs and should continue, although Matic in particular did look some way off the pace on Monday.
Diogo Dalot is back in training after knee surgery and could feature soon, while Sergio Romero and Marcos Rojo are still out after summer operations.
Alexis Sanchez should be fit to start having returned from injury with a second-half substitute appearance last time out, while Phil Jones is expected to be unavailable having picked up a hamstring injury in the heavy defeat to Tottenham.
Man Utd Suspensions
Neither team has any suspension concerns, with none of their players sent off in the opening games of this term.
Man Utd Starting Line-Up
The trip to Burnley is unlikely to feature more of the tactical tinkering from Jose Mourinho which saw him pick Ander Herrera as a centre-back in the 3-0 reverse to Spurs, with the Spaniard either being chosen as one of the substitutes or potentially covering for Nemanja Matic in midfield if the Serb suffers any reaction to his comeback appearance on Monday.
With Alexis Sanchez back, the Chilean ought to line up on the left of the attack, while Victor Lindelof and Eric Bailly will be battling for the starting shirt alongside Chris Smalling to replace Phil Jones at the back following the England World Cup defender's hamstring issue on Monday.
Burnley Team News
Sean Dyche's side have suffered a frustrating start to the season, with their Europa League campaign having seen them past Aberdeen and Basaksehir only to be eliminated by Olympiakos in the play-off round on Thursday.
They have also struggled in the Premier League - perhaps as a result of their extra workload in Europe - and have picked up only a single point from their first three games. Their opening day draw was followed by disappointing defeats to Watford and Fulham as the Clarets showed a defensive deficiency which barely existed at all during their excellent 2017-18 season.
Dyche's biggest call might come in choosing a goalkeeper, with Tom Heaton having returned to full fitness following a calf problem. The former United goalkeeper has already played in their European loss against Olympiakos but Joe Hart has until now retained the gloves in the Premier League in the continued absence of Nick Pope after the World Cup back-up damaged his shoulder against Aberdeen in July.
Elsewhere the manager will be hoping to get his strikers firing, with defender James Tarkowski having scored two of Burnley's league goals so far this season and Jeff Hendrick getting the other.
TV Channel & Kick-off time
The match at Turf Moor kicks off at 4pm BST on Sunday, but there is no live coverage in the UK since the game between Watford and Tottenham was selected for TV long before Burnley's Europa League adventures forced a rescheduling of this fixture. In the U.S. the game will be shown on NBCSN at 11am ET.
Best Opta Match facts
Burnley have won just one of their last 17 top-flight meetings with Manchester United (D8 L8), with that victory coming in their first ever Premier League meeting back in August 2009 (1-0).
Manchester United have kept a clean sheet on nine of their last 10 visits to Turf Moor in all competitions, with the exception being a 0-1 defeat in August 2009.
Burnley are occupying the bottom three of the Premier League for the first time since August 2016 – however, the Clarets have won three of their last four Premier League matches when starting the day in the relegation zone (D1).
Manchester United have lost two of their first three league matches of a season for the first time since 1992-93 (P3 W0 D1 L2) – they haven’t lost three of their first four league matches in a season since 1986-87, when they were managed by Ron Atkinson.
Burnley have collected just nine home points in the Premier League in 2018 (P10 W2 D3 L5) – only Huddersfield (8) and Southampton (7) have won fewer among clubs ever-present this calendar year.
English managers have collected just four points in their last 21 Premier League matches against Man Utd (W0 D4 L17) since Sam Allardyce led his Sunderland side to a 2-1 win in February 2016.
Since Jose Mourinho took charge of Manchester United, he has won all 11 of his away Premier League matches against Englishmen, with two of those victories coming against Sean Dyche’s Burnley.
Burnley are still yet to make a change to their starting XI in the Premier League this season, while Man Utd have made more changes than any other side (9).
Manchester United’s goal difference of minus three is their worst since August 1992, when they had the same negative deficit after four matches of the inaugural Premier League season; this is the first time they will be going into a Premier League match with a negative goal difference since September 2014, when they beat QPR 4-0 following a 0-0 draw away at Burnley in the previous match.
Burnley have conceded 14 goals in their last five Premier League games – one more than in their previous 14 games combined (13).