Southampton provide the opposition for Pep Guardiola's side and only need to avoid a big defeat in order to stay in the Premier League next season.
But, with the champions having already scored a record-breaking 105 Premier League goals this season and needing the three points to reach the century, there could still be a few uncomfortable moments for Southampton's former City manager Mark Hughes.
Man City injuries
The only player set to miss out for City through injury is Sergio Aguero, who has an ongoing knee problem. Belgium international Vincent Kompany won't be risked from the start ahead of the World Cup.
Man City suspensions
Man City have no suspended players for this game.
Confirmed Man City starting line-up
There's no dream send-off for Yaya Toure, who misses out on the starting line-up and bench, while Benjamin Mendy is rested by Guardiola.
Bernardo Silva, Leroy Sane and Raheem Sterling start in a pacy attack, while John Stones and Aymeric Laporte are favoured in centre defence.
Kevin De Bruyne and Fernandinho have been ever-present in midfield and start again in their final game of 2017-18, alongside Ilkay Gundogan.
Claudio Bravo is favoured in goal to usual first-choice shot-stopper Ederson. Garbiel Jesus and Kyle Walker are heavyweight options on the bench.
Man City confirmed line-up vs Southampton: Bravo, Danilo, Stones, Laporte, Delph, Fernandinho, Gundogan, De Bruyne, B Silva, Sane, Sterling
Southampton team news
Southampton are expected to play as defensively as possible as they only need to avoid a heavy defeat to stay up, and that is only if Swansea beat Stoke.
Maya Yoshida's suspension period is over. Sofiane Boufal and Steven Davis are both injured, while Mario Lemina is a doubt.
Best Opta match facts
Man City have won two of their last three visits to St Mary’s in the Premier League (L1), with both victories being by a scoreline of 3-0.
Before becoming Manchester City manager in 2008, Mark Hughes was unbeaten against them in the Premier League (W4 D4 L0). Since leaving, he’s won only two of his 13 league meetings against City (D3 L8).
Indeed, victory for City would also see them create a new record for most away wins (16) and points (50) in a Premier League season
If Manchester City win, they’ll be the first team to ever reach 100 points in an English top-flight campaign, breaking Liverpool’s previous record of 98 in 1978-79 (adjusted to 3 points for a win).
Southampton haven’t kept a clean sheet in any of their last 12 Premier League games against Man City, shipping 27 goals in total.
TV channel & kick-off time
The match kicks off at 3pm BST (10am ET) on Sunday with TV coverage available on Sky Sports.