Pep Guardiola named a surprisingly strong team for the Blues' Champions League game against Feyenoord on Tuesday night but did manage to rest some key players, including Fernandinho, David Silva and Leroy Sane.
They are likely to come back into the team as Guardiola reverts to something like his best line-up.
MAN CITY INJURIES
John Stones injured his hamstring at Leicester last weekend and is likely to be out until the end of December. Vincent Kompany made his well-timed return in the same game and after being rested against Feyenoord he is in line to start at Huddersfield.
David Silva was rested in midweek but he also has an ongoing neck problem, although it should not stop him from playing this weekend.
Benjamin Mendy is a long-term absentee.
MAN CITY SUSPENSIONS
Neither Manchester City nor Huddersfield have any suspensions.
MAN CITY POTENTIAL STARTING LINE-UP
Barring any surprise injuries, or a flare-up of David Silva's neck problem, City's team could be relatively straightforward to predict.
Kompany will partner Nicolas Otamendi at the back, providing the Belgian feels comfortable following his return to action a week ago. Fabian Delph has impressed at left-back and is likely to come back in after seeing Danilo play in midweek.
Fernandinho, Kevin De Bruyne and Silva make up City's first-choice midfield, while Leroy Sane and Raheem Sterling provide the width in attack.
Guardiola says his toughest decision is whether to pick Sergio Aguero or Gabriel Jesus, and as ever it seems, from the outside at least, that each player has a 50 per cent chance of playing.
HUDDERSFIELD TEAM NEWS
Huddersfield are 10th in the table with four wins to their name, though two those victories came in the first two weeks of the season.
Since then they have won twice in 10 attempts, although they did shock Manchester United at the John Smith's Stadium at the end of October.
They will be without centre-back Michael Hefele (Achilles) and Philip Billing (ankle), while Jon Stankovic has had a set-back in his recovery from a knee injury.
Kasey Palmer has recovered from a hamstring injury he picked up in September and could be in contention, though he is lacking match fitness.
OPTA MATCH FACTS
- Huddersfield held Pep Guardiola’s Man City to a goalless draw in an FA Cup fifth round tie at the John Smith’s Stadium last season, before losing the replay 1-5.
- Manchester City beat Huddersfield 10-1 in a league match in November 1987 – to date, it’s the last time a club has scored 10+ goals in an English league match.
- Manchester City have won their last 10 away games in all competitions - a win at Huddersfield would create a new record among English top-flight clubs for consecutive away wins.
- Huddersfield conceded just three goals and 4.5% of opposition shots in their first six Premier League games this season, but have shipped 14 goals and 21.9% of opponent shots in their last six matches in the competition.
- If Manchester City win this match, they’ll have 37 points and the outright best points tally of a side after 13 games of a Premier League season – beating their own record set in 2011-12 (35).
- David Silva has been involved in the build-up to 85 shots that Manchester City have attempted from open play in the Premier League this season; more than any other player for their club.
TV COVERAGE & KICK-OFF TIME
Kick off is 16:00 GMT with the game to be shown live on Sky Sports Premier League, Sky Sports Main Event and streamed through the Sky Sports app.