Spurs enjoyed a fantastic 4-1 win against the Reds when they met at Wembley back in October, but Jurgen Klopp's charges will fancy their chances of avenging that defeat.
Liverpool saw a 19-match unbeaten run at Anfield ended by West Bromwich Albion in the FA Cup fourth round last weekend, but the Reds will be determined to give the home supporters something to cheer here.
Paddy Power offer even money (2.0) that Klopp's side take all three points against Mauricio Pochettino's team.
Spurs have stuttered on their travels in recent months, winning just two of their last seven matches away from Wembley and Paddy Power go 13/5 (3.60) that Tottenham bounce back with victory on Merseyside.
The odds compilers also offer 11/4 (3.75) that both sides are forced to settle for a share of the spoils.
With 36 league goals between them this season, Sadio Mane, Roberto Firmino and Mohamed Salah pose a significant threat to Spurs.
Harry Kane will lead the visitors' attack, while Lucas Moura, signed from Paris Saint-Germain, is in line for his debut.
Both teams possess plenty of quality in the final third and Paddy Power go 8/13 (1.62) that there are more than two goals scored in this game.
It is worth noting, though, that the selection would have failed to land in four of the last six meetings between the teams and Paddy Power's 5/4 (2.25) quote for fewer than three goals to be scored may prove popular with punters.
Tips and predictions
Despite a number of low-scoring matches between these teams in recent seasons, there remains plenty of potential for fireworks when this rivalry is renewed.
The 6/4 (2.50) quote from Paddy Power, therefore, for more than three goals to be scored could represent excellent value for punters ahead of Sunday's showdown at Anfield.
Risk Free 20: New customers only, limited to one per person. If you’ve previously had a Paddy Power account, you will not qualify for the offer. Place your FIRST bet on any Sportsbook market and if it loses we will refund your stake in CASH. Max refund for this offer is €20. Only deposits made using Cards or Paypal will qualify for this promotion. T&Cs apply. Paddy's Rewards Club: Get a €10 free bet when you place 5x bets of €10+. T&Cs apply.