The Reds have collected 15 points from the first possible 15 in the league, and recorded a dramatic 3-2 victory over PSG in their opening Champions League fixture on Tuesday.
Having won both of last season’s league encounters with this opposition, Jurgen Klopp's outfit are 2/11 (1.18) favourites with 888Sport to extend their 100 per cent record by coming out on top once again.
Unbeaten in three matches, Mark Hughes’ team can be backed at 15/1 (16.00) to pull off a shock victory at this ground for the first time since 2013.
The guests have actually claimed a point in two of their previous three league visits to Anfield, and are priced at 6/1 (7.00) to earn a share of the spoils once again in this one.
Dejan Lovren is still unlikely to feature despite returning to training, with Alex Oxlade Chamberlain and Adam Lallana also still ruled out through injury.
The Saints have no injury concerns but will be without the on-loan Danny Ings, who is ineligible to face his parent club.
Top scorer with three goals in his last four matches, Ings’ absence is a major blow for a team that has struggled for cutting edge over the last couple of seasons.
However, Hughes should be feeling more confident of his team putting in a strong defensive performances, having put in plenty of work with the backline since taking over.
A run of just three goals conceded in the final five matches of last season helped to steer Southampton clear of relegation, while they have let in a respectable six times in their opening six fixtures this campaign.
With Liverpool’s attack not quite hitting top gear so far this season, odds of 10/11 (1.91) seem generous on the guests restricting them to under 2.5 goals for their fifth consecutive league match.