Jurgen Klopp's men have taken six points from six so far, following up a big 4-0 home win over West Ham with a gritty 2-0 victory away at Crystal Palace.
Having won each of their last five matches against this opposition, they are 1/6 (1.17) favourites with bet365 to maintain their 100 per cent record here.
However, the Seagulls recorded a shock 3-2 win over Manchester United last weekend, and are available at 14/1 (15.00) to pull off another upset by coming out on top, or 6/1 (7.00) to earn a hard-fought point.
Alex Oxlade-Chamberlain is a long-term injury lay-off, while Dejan Lovren remains some way off full fitness.
Lewis Dunk looks set to miss out after suffering an ankle injury versus Manchester United, joining Bruno, Florin Andone and Jose Izquierdo in the treatment room.
Although he has now overseen consecutive victories over Manchester United, Chris Hughton's record against this opposition is far less impressive.
The former Norwich City boss has lost all five of his Premier League matches against the Reds, with his sides conceding at least four goals in every game - including nine over two encounters last season.
Having scored three goals but conceded twice last weekend, Brighton look set for yet another high-scoring clash against a home team that has scored 35 goals in their last 11 league fixtures in front of their own fans.
Indeed, odds of 10/11 (1.91) look generous on over 3.5 goals being scored for the seventh meeting in eight between this pair.
Odds correct at the time of writing. Please gamble responsibly.