The pair were named as substitutes in the 3-0 away victory over Stoke on Wednesday, with the Egyptian coming off the bench to score twice.
The Senegal international, who got a goal and an assist against Mark Hughes’ side, is held in reserve on the south coast.
Jurgen Klopp has made six changes in total to the line-up, which includes a defensive reshuffle.
Joel Matip’s absence through an adductor injury should see Emre Can move to the heart of defence alongside Dejan Lovren, with Ragnar Klavan only fit enough for the bench after illness.
Joe Gomez, who would’ve ordinarily provided cover at centre-back, is not included in the 18 as he’s laid low with a virus.
Trent Alexander-Arnold comes in for the England international on the right of the defence, while Alberto Moreno is rested with Andy Robertson getting a rare run-out at left-back.
Jordan Henderson resumes duties at the base of midfield having been on the bench at Stoke, with James Milner taking Alex Oxlade-Chamberlain’s starting spot.
Simon Mignolet makes his 150th Premier League appearance for Liverpool.
Liverpool starting XI: Mignolet, Alexander-Arnold, Can, Lovren, Robertson, Henderson, Milner, Wijnaldum, Coutinho, Salah, Firmino. Subs: Karius, Klavan, Grujic, Oxlade-Chamberlain, Mane, Solanke, Sturridge.